Intermediate suppl exam results
Karachi, March 10, 2008: The Board of Intermediate Education (BIE), Karachi,
will announce the results of HSC Part-II (Pre-medical) supplementary
examinations, 2007 on Monday while the results of HSC (Pre-engineering and
general science groups) supplementary exams, 2007 will be made public on Tuesday
According to BIEK chairman Prof Anwar Ahmed Zai, the
compilation work of the remaining examination results of other groups such as
HSC Part-II (Arts) (for both private and regular) students and the SHC Part-II
(Commerce) supplementary examinations, 2007 would also be completed in a couple
of days and announced by the end of the current week. Dawn
"assalm o alikum,2nd year commerce ka result kab aye ga? "
City, Country: karachi
New data on anti-anxiety pill tolerance from KU
Karachi: Researchers at the
University of Karachi have found fresh data on tolerance to anti-anxiety
medication and its links to responsiveness of serotonin receptors, Drug Week
reported March 7.
The data on life sciences are presented in the report
'Tolerance in the anxiolytic profile following repeated administration of
diazepam but not buspirone is associated with a decrease in the responsiveness
of postsynaptic 5-HT-1A receptors.' The research was published in the journal
Acta Biologica Hungarica. It aimed to understand the role of serotonin receptors
in the treatment of anxiety and the development of tolerance to benzodiazepines.
The study was designed to monitor the responsiveness of postsynaptic 5-HT-1A
receptors following repeated administration of diazepam and buspirone.
Diazepam was first marketed as Valium by Hoffmann-La Roche. It is a
benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant,
sedative, skeletal muscle relaxant and amnestic properties. It is commonly used
for treating anxiety, insomnia, seizures, alcohol withdrawal, and muscle spasms.
Buspirone (brand-names Ansial, Ansiced, Anxiron, Axoren, Bespar, BuSpar,
Buspimen, Buspinol, Buspisal, Narol, Spitomin, Sorbon) is an anxiolytic agent
and a serotonin receptor agonist belonging to the azaspirodecanedione class of
compounds. Its structure is unrelated to those of the benzodiazepines, but it
has an efficacy comparable to diazepam in treating generalized anxiety disorder.
The results showed that tolerance in the anxiolytic or anti-anxiety
profile was produced following repeated administration (2 weeks) of diazepam (2
mg/kg) but not buspirone (0.5 mg/kg).
"The behavioral effects of
8-OH-DPAT at a dose of 0.25 mg/kg were monitored 3 days after repeated
administration of saline or buspirone or diazepam. The results show that
8-OH-DPAT elicited forepaw treading was smaller in repeated diazepam but not
repeated buspirone injected rats, while hyperlocomotive effects of 8-OH-DPAT
were smaller in both repeated buspirone and repeated diazepam injected rats. The
results suggest that postsynaptic 5-HT-1A receptor-dependent responses were
attenuated following long-term administration of diazepam but not buspirone,"
wrote A. Khan and colleagues. Daily Times